Novel non-coding transcripts at imprinted loci in mammalian oocytes and embryos

Nina NENIN

Bakalářská práce

Abstract:

Aims of this thesis were to annotate novel transcripts within clusters of imprinted genes in mouse oocytes and embryo, to analyze expression changes of these transcripts during mouse embryonic development, to identify enriched sequence motifs and potential transcription factors binding sites at promoters of transcripts within imprinted gene clusters as well as transposable elements acting as promoters of these transcripts and to identify potential candidates for further functional studies, using bioinformatic methods.

Abstract:

Aims of this thesis were to annotate novel transcripts within clusters of imprinted genes in mouse oocytes and embryo, to analyze expression changes of these transcripts during mouse embryonic development, to identify enriched sequence motifs and potential transcription factors binding sites at promoters of transcripts within imprinted gene clusters as well as transposable elements acting as promoters of these transcripts and to identify potential candidates for further functional studies, using bioinformatic methods.

Keywords

genetics, bioinformatics, imprinting in mammals, novel trananscripts, expression analysis, imprinted genes, mouse transcriptome, transcription factors, regulation of imprinting, transposable elements

Jazyk práce: angličtina

Datum vytvoření / odevzdání či podání práce: 22. 11. 2019

Obhajoba závěrečné práce

• Vedoucí: Mgr. Lenka Gahurová, Ph.D.

JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH

Přírodovědecká fakulta

Bakalářský studijní program / obor:
Biochemistry / Biological Chemistry