Mgr. Kateřina Zábrady, Ph.D.

Doctoral thesis

Analysis of MAGE (Melanoma AntiGEn) proteins and their interaction partners

Analysis of MAGE (Melanoma AntiGEn) proteins and their interaction partners
Abstract:
Doposud bylo u člověka identifikováno 37 MAGE (melanoma-associated antigen) genů. Na základě rozdílů jejich genové exprese a struktury je skupina MAGE genů rozdělena na typ I and II. Exprese MAGE genů typu I je utlumena v dospělých buňkách normálních tkání, ale je aktivována v různých maligních nádorech. MAGE geny typu II jsou exprimovány téměř ve všech tkáních. O funkcích MAGE proteinů v buňkách zatím …more
Abstract:
To date, 37 melanoma-associated antigen (MAGE) genes have been identified in humans. The large MAGE family is divided into type I and II based on differences in tissue-specific gene expression and gene structure. Type I MAGE genes are silent in normal adult cells, while they are widely expressed in a variety of malignant tumors. Type II MAGE genes are expressed ubiquitously. However, little is known …more
 
 
Language used: English
Date on which the thesis was submitted / produced: 10. 3. 2015

Thesis defence

  • Date of defence: 29. 4. 2015
  • Supervisor: doc. Mgr. Jan Paleček, Dr. rer. nat.
  • Reader: doc. RNDr. Miroslav Fojta, CSc., doc. Juraj Gregáň, PhD.

Citation record

Full text of thesis

Contents of on-line thesis archive
Published in Theses:
  • světu
Other ways of accessing the text
Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta

Masaryk University

Faculty of Science

Doctoral programme / field:
Biochemistry (4-years) / Genomics and Proteomics