A role of Sirt1 in the Notch signalling pathway. – Mgr. Matej HORVÁTH
Mgr. Matej HORVÁTH
Doctoral thesis
A role of Sirt1 in the Notch signalling pathway.
Abstract:
The aim of this thesis was to examine role of Sirt1 in the Notch signalling pathway, using Drosophila as a model organism. Based on in vivo and in vitro studies, we conclude that Sirt1 plays a positive role in Notch signalling. In embryonic S2N cells, Sirt1 is responsible for the protection from metabolic stress-induced down-regulation of subset of E(Spl) genes. During development, Sirt1 is responsible …moreAbstract:
The aim of this thesis was to examine role of Sirt1 in the Notch signalling pathway, using Drosophila as a model organism. Based on in vivo and in vitro studies, we conclude that Sirt1 plays a positive role in Notch signalling. In embryonic S2N cells, Sirt1 is responsible for the protection from metabolic stress-induced down-regulation of subset of E(Spl) genes. During development, Sirt1 is responsible …more
Language used: English
Date on which the thesis was submitted / produced: 29. 5. 2017
Thesis defence
- Supervisor: RNDr. Alena Bruce, Ph.D.
Citation record
ISO 690-compliant citation record:
HORVÁTH, Matej. \textit{A role of Sirt1 in the Notch signalling pathway.}. Online. Doctoral theses, Dissertations. České Budějovice: University of South Bohemia in České Budějovice, Faculty of Science. 2017. Available from: https://theses.cz/id/ysb4wd/.
The right form of listing the thesis as a source quoted
HORVÁTH, Matej. A role of Sirt1 in the Notch signalling pathway.. Č. Budějovice, 2017. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
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Institution archiving the thesis and making it accessible: JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH, Přírodovědecká fakultaUNIVERSITY OF SOUTH BOHEMIA IN ČESKÉ BUDĚJOVICE
Faculty of ScienceDoctoral programme / field:
Molecular and Cell Biology / Molecular and Cell Biology and Genetics
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