Three-Dimensional Visualization of Tick-Borne Encephalitis Virus Infection in Mouse Brain Tissue

Sarah GAHBAUER

Bakalářská práce

Abstract:

Tick-borne Encephalitis Virus (TBEV) is an important human pathogen that causes serious neuroinfections such as inflammation of the brain (encephalitis), the lining of the brain (meningitis), and the spinal cord (myelitis). The exact mechanism by which the virus enters the brain remains an unsolved problem. However, the virus is known to infect several cells in the brain, such as glial cells and neurons. This thesis focusses on the ultrastructural changes induced by infection in the mouse brain. A special focus was placed on the endothelium during infection and to determine if or how endothelial cells can be infected to reconstruct possible entry routes of the virus into the brain.

Abstract:

Tick-borne Encephalitis Virus (TBEV) is an important human pathogen that causes serious neuroinfections such as inflammation of the brain (encephalitis), the lining of the brain (meningitis), and the spinal cord (myelitis). The exact mechanism by which the virus enters the brain remains an unsolved problem. However, the virus is known to infect several cells in the brain, such as glial cells and neurons. This thesis focusses on the ultrastructural changes induced by infection in the mouse brain. A special focus was placed on the endothelium during infection and to determine if or how endothelial cells can be infected to reconstruct possible entry routes of the virus into the brain.

Keywords

Tick borne encephalitis virus, Neuroinfections, Ultrastructural changes, Autophagy, Membranous whorls, Blood brain barrier

Jazyk práce: angličtina

Datum vytvoření / odevzdání či podání práce: 11. 5. 2023

Obhajoba závěrečné práce

• Vedoucí: RNDr. Marie Vancová, Ph.D.

JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH

Přírodovědecká fakulta

Bakalářský studijní program / obor:
Biological Chemistry / Biological Chemistry