Bc. Petra Martinková

Bachelor's thesis

Vliv exprese proteinů CPB1 a PDLIM2 na prometastatické vlastnosti nádorových buněk

The role of CPB1 and PDLIM2 protein expression on prometastatic properties of tumor cells
Abstract:
Tato bakalářská práce se zabývá vlivem exprese proteinů karboxypeptidázay B1 (CPB1) a „PDZ and LIM domain protein 2“ (PDLIM2) na prometastatické vlastnosti nádorové buněčné linie MCF-7. V teoretické části jsou popsány vlastnosti těchto proteinů a také jejich úloha v nádorové biologii. Dále je v teoretické části popsána buněčná linie MCF-7 a „patient derived xenografts“ (PDX). V experimentální části …more
Abstract:
In this thesis, we focused on impact of carboxypeptidase B1 (CPB1) and PDZ and LIM domain protein 2 (PDLIM2) expression on prometastatic properties of cell line MCF-7. In the theory part these proteins are described and their role in the tumour biology. Next, cell lines MCF-7 and patients derived xenografts (PDX) were described in the theoretical part. In the experimental part of the thesis was examined …more
 
 
Language used: Czech
Date on which the thesis was submitted / produced: 15. 5. 2017

Thesis defence

  • Date of defence: 13. 6. 2017
  • Supervisor: doc. Mgr. Pavel Bouchal, Ph.D.

Citation record

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta