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Bc. Peter Holub, Ph.D.

Master's thesis

Proteinové inženýrství halogenalkandehalogenasy LinB: změna reakčního mechanismu

Protein engineering of haloalkane dehalogenase LinB: Towards the change of reaction mechanism
Abstract:
Haloalkane dehalogenases are microbial hydrolases catalyzing removal of halogens from aliphatic hydrocarbons. Based on structural and sequence similarities between haloalkane dehalogenase LinB and luciferase from Renilla reniformis, we propose that it could be possible to construct a mutant of LinB with luminescence activity or to obtain an enzyme with both luminescence and dehalogenase activities …more
 

Keywords

Enzyme reaction mechanism dehalogenase luciferase luminescence directed evolution high-throughput screening
 
Language used: English
Date on which the thesis was submitted / produced: 30. 4. 2008
Identifier: https://is.muni.cz/th/hay2c/

Thesis defence

  • Date of defence: 9. 6. 2008
  • Supervisor: prof. Mgr. Jiří Damborský, Dr.
  • Reader: doc. Mgr. Štěpánka Vaňáčová, Ph.D.

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta
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