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Mgr. Barbora Štefanovie

Bachelor's thesis

Characterizace vlivu DSS1 proteinu na aktivitu BRCA2

Characterization of DSS1 effect on BRCA2 activties
Abstract:
Homologous recombination is an important mechanism of the repair of damaged DNA. It is indispensable for genome integrity, but it must be tightly regulated to avoid deleterious events. The breast cancer susceptibility protein BRCA2 is essential for recombinational DNA repair. BRCA2 binds an evolutionarily conserved acidic protein DSS1, but the functional significance of this interaction has remained …more
Abstract:
Homologická rekombinácia predstavuje významný mechanizmus opravy DNA. Hrá kľúčovú úlohu pri udržovaní integrity genómu a preto musí byť veľmi prísne regulovaná. BRCA2, proteín spájaný s predispozíciou k rakovine pŕs, je nevyhnutný pre priebeh rekombinačnej opravy DNA. BRCA2 viaže malý kyslý proteín s vysoko konzervatívnou štruktúrou, DSS1. Význam tejto interakcie však nie je doposiaľ známy. Bakalárska …more
 

Keywords

homologická rekombinácia HR dvojvláknové zlomy DSB BRCA2 DSS1
 
Language used: Slovak
Date on which the thesis was submitted / produced: 14. 5. 2009
Identifier: https://is.muni.cz/th/igzn3/

Thesis defence

  • Date of defence: 16. 6. 2009
  • Supervisor: doc. Mgr. Lumír Krejčí, Ph.D.

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta
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Masaryk University

Faculty of Science

Bachelor programme / field:
Biochemistry / Biochemistry

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