Bc. Aleš Novotný

Master's thesis

Struktura d(GA) repetic stabilizovaných i-motivem

Structure of d(GA) repeats stabilized by i-motif
Abstract:
Tato diplomová práce se zabývá strukturou GA repetic stabilizovaných i-motivem a vzájemnou souhrou těchto dvou strukturních motivů. Dále se práce zabývá interkalačními topologiemi i-motivu, zejména tedy vlivem substituce cytosinu za 5-methylcytosinu na preferovanou topologii i-motivu. Oligonukleotidy byly studovány pomocí nukleární magnetické rezonance a CD spektroskopie.
Abstract:
This master thesis deals with structure of GA repetitions stabilized by i-motif and with interplay of these two structural motifs. Also, the thesis deals with intercalation topologies of-motif, especially with the effect of 5-methylcytosine for cytosine substitution on the preferred i-motif topology. Oligonucleotides were studied by nuclear magnetic resonance and CD spectroscopy.
 
 
Language used: English
Date on which the thesis was submitted / produced: 16. 5. 2019

Thesis defence

  • Date of defence: 5. 6. 2019
  • Supervisor: Mgr. Jan Novotný, Ph.D.
  • Reader: doc. Mgr. Lukáš Trantírek, Ph.D.

Citation record

Full text of thesis

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Masaryk University

Faculty of Science

Master programme / field:
Chemistry / Structural Chemistry