Bc. Ivana Vasarábová

Master's thesis

Regulace dynamiky SMC5/6 komplexu

Regulation of SMC5/6 complex dynamics
Abstract:
SMC5/6 komplex je vysoce konzervovaný proteinový komplex, který patří do rodiny SMC proteinovych komplexů. SMC komplexy jsou klíčové faktory při udržování stability chromatinu. SMC5/6 komplex je zapojen do mnoha buněčných procesů, jako je stabilizace zastavených replikačních vidlic a opravy poškození DNA. Komplex má nejspíše kruhovou strukturu, která topologicky váže DNA, nicméně mechanismus zavedení …more
Abstract:
SMC5/6 complex is a highly conserved protein complex that belongs to the protein family of the SMC complexes, which are the key factors of the chromatin structural maintenance. The SMC5/6 complex is involved in many actions such as stabilization of stalled replication forks and DNA damage repair. Presumably, the complex has a „ring-like“ structure by which topologically entraps DNA, however, the mechanism …more
 
 
Language used: English
Date on which the thesis was submitted / produced: 15. 5. 2017

Thesis defence

  • Date of defence: 9. 6. 2017
  • Supervisor: doc. Mgr. Jan Paleček, Dr. rer. nat.
  • Reader: Mgr. Kateřina Zábrady, Ph.D.

Citation record

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta

Masaryk University

Faculty of Science

Master programme / field:
Biochemistry / Genomics and Proteomics