The role of cellular stress and tick salivary compounds in tick-borne encephalitis virus infection

Mgr. Zuzana BERÁNKOVÁ

Disertační práce

Abstract:

This Ph.D. thesis explores the cellular stress responses induced by tick-borne encephalitis virus (TBEV) infection, focusing on the effect of these responses on viral replication. Additionally, the work investigates how these processes are modulated by the saliva and salivary protein of the tick Ixodes ricinus. The research reveals the dual role of autophagy in regulating TBEV replication within mouse macrophages and shows the intricate interplay between host cellular stress mechanisms and viral propagation. Furthermore, the study demonstrates how tick saliva and its components influence the replication of TBEV, contributing to our understanding of vector-pathogen-host interactions.

Abstract:

This Ph.D. thesis explores the cellular stress responses induced by tick-borne encephalitis virus (TBEV) infection, focusing on the effect of these responses on viral replication. Additionally, the work investigates how these processes are modulated by the saliva and salivary protein of the tick Ixodes ricinus. The research reveals the dual role of autophagy in regulating TBEV replication within mouse macrophages and shows the intricate interplay between host cellular stress mechanisms and viral propagation. Furthermore, the study demonstrates how tick saliva and its components influence the replication of TBEV, contributing to our understanding of vector-pathogen-host interactions.

Keywords

tick-borne encephalitis virus, cellular stress, ER stress, oxidative stress, autophagy, tick saliva, tick salivary proteins, Ixodes ricinus

Jazyk práce: angličtina

Datum vytvoření / odevzdání či podání práce: 14. 10. 2024

Obhajoba závěrečné práce

• Vedoucí: doc. Mgr. Jaroslava Lieskovská, Ph.D.

JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH

Přírodovědecká fakulta

Doktorský studijní program / obor:
Biologie / Infekční biologie