Metallochelating nanoliposomes for construction of recombinant vaccines – PharmDr. Bc. Josef Mašek, Ph.D.
PharmDr. Bc. Josef Mašek, Ph.D.
Doctoral thesis
Metallochelating nanoliposomes for construction of recombinant vaccines
Metallochelating nanoliposomes for construction of recombinant vaccines
Abstract:
Liposomy představují nosiče vakcín, které vykazují adjuvantní aktivitu k neseným proteinovým antigenům. Metalochelatační liposomy jsou navrženy pro vazbu His-tagovaných proteinů nekovalentní interakcí. Tyto liposomy byly připraveny ze směsi fosfatidylcholinu a metalochelatačního lipidu DOGS-NTA-Ni metodou odstranění detergentu a metodou hydratace lipidního filmu s následnou extruzí. Jako molekulární …moreAbstract:
Liposomes represent nanoscale-based formulations showing a potent adjuvant activity to protein antigens. Metallochelating liposomes were designed to attach His-tagged protein by non-covalent interaction. Metallochelating liposomes were prepared from the mixture of egg phosphatidyl choline and nickel-chelating lipid DOGS-NTA-Ni by the detergent-removal method and by hydration of a lipid film followed …more
Language used: English
Date on which the thesis was submitted / produced: 18. 4. 2013
Identifier:
https://is.muni.cz/th/xn9om/
Thesis defence
- Date of defence: 10. 6. 2013
- Supervisor: doc. RNDr. Jaroslav Turánek, CSc.
- Reader: doc. PharmDr. Kateřina Dvořáčková, PhD., prof. RNDr. Jan Krejsek, CSc.
Citation record
ISO 690-compliant citation record:
MAŠEK, Josef. \textit{Metallochelating nanoliposomes for construction of recombinant vaccines}. Online. Doctoral theses, Dissertations. Brno: Masaryk University, Faculty of Science. 2013. Available from: https://theses.cz/id/jq7ozq/.
Full text of thesis
Contents of on-line thesis archive
Published in Theses:- světu
Other ways of accessing the text
Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakultaMasaryk University
Faculty of ScienceDoctoral programme / field:
Biochemistry (4-years) / Biochemistry
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