Elucidating the source of bloodstream \kur{Trypanosoma brucei} mitochondrial ATP

Bc. Michaela HUSOVÁ

Diplomová práce

Abstract:

For decades, it has been assumed that the reduced function and structure of the bloodstream form Trypanosoma brucei mitochondrion renders it a strictly ATP consuming organelle. Emerging evidence from refocused studies suggest that the bloodstream mitochondrion retains complex bioenergetic pathways that allow the parasite to adapt to various environments. This thesis is focused on the source of bloodstream mitochondrial ATP, with a special emphasis on the role of succinyl-CoA to produce ATP via mitochondrial substrate phosphorylation. We will also discuss alternative bioenergetic pathways present in this life stage of a human pathogen.

Abstract:

For decades, it has been assumed that the reduced function and structure of the bloodstream form Trypanosoma brucei mitochondrion renders it a strictly ATP consuming organelle. Emerging evidence from refocused studies suggest that the bloodstream mitochondrion retains complex bioenergetic pathways that allow the parasite to adapt to various environments. This thesis is focused on the source of bloodstream mitochondrial ATP, with a special emphasis on the role of succinyl-CoA to produce ATP via mitochondrial substrate phosphorylation. We will also discuss alternative bioenergetic pathways present in this life stage of a human pathogen.

Keywords

Trypanosoma brucei, mitochondria, bioenergetics, substrate phosphorylation, succinyl coenzyme A

Jazyk práce: angličtina

Datum vytvoření / odevzdání či podání práce: 12. 4. 2021

Obhajoba závěrečné práce

• Vedoucí: RNDr. Alena Zíková, Ph.D.

JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH

Přírodovědecká fakulta

Magisterský studijní program / obor:
Biologie / Experimentální biologie - specializace Molekulární a buněčná biologie a genetika