Syntéza monokvarterních reaktivátorů acetylcholinesterasy nesoucích (alkoxymethylen)bis-benzenový periferní ligand

Eva Vepřková

Bakalářská práce

Synthesis of monoquaternary acetylcholinesterase reactivators bearing (alcoxymethylene)bis-benzene peripheral ligand

Abstract:

The main aim of this Bachelor Thesis was synthesis of monoquaternary acetylcholinesterase reactivators bearing lipophilic peripheral site ligand. The Bachelor Thesis is divided into two parts, theoretical and experimental. The theoretical part deals with the issue of nerve agent intoxication and their current antidotal therapy. The antidotal therapy of nerve agent poisoning consists in administration of anticholinergics, anticonvulsants and oxime reactivators. The main aim of the experimental part was synthesis of so-called dual site acetylcholineseterase reactivators that were prepared by conjugation of 4-pyridinealdoxime and lipophilic benzhydryl moiety via aliphatic linkers of various length. An additional aim of the experimental part of given Bachelor Thesis was biological evaluation of prepared compounds. Within such testing, the inhibitory activity of novel reactivators towards cholinesterases as well as their reactivation potential was determined.

Keywords

Acetylcholinesterase, Nerve agents, Antidotal therapy, Oxime reactivators

Jazyk práce: angličtina

Datum vytvoření / odevzdání či podání práce: 10. 5. 2021

Obhajoba závěrečné práce

• Obhajoba proběhla 8. 6. 2021
• Vedoucí: Mgr. Eugenie Nepovimová, Ph.D.
• Oponent: RNDr. Patrik Olekšák, PhD.

Univerzita Hradec Králové

Přírodovědecká fakulta

Bakalářský studijní program / obor:
Chemie / Toxikologie a analýza škodlivin