Bc. Peter Macsek

Master's thesis

Role NDRG1 v regulaci EGFR signalizace u neuroblastomu

The role of NDRG1 in EGFR signaling of neuroblastoma
Abstract:
Protinádorové účinky proteinu NDRG1 (N-myc downstream-regulated gene 1) jsou předmětem studia již téměř dvě desetiletí. Nedávno byla částečně objasněna jejich role v regulaci EGFR (Epidermal growth factor receptor) signalizace u karcinomu pankreatu. Navíc, nová terapeutika ze skupiny thiosemikarbazonů dokázala navýšit expresi genu NDRG1, čímž umožňují propagaci jeho antineoplastických účinků. Buněčný …more
Abstract:
Tumor suppressive effects of NDRG1 (N-myc downstream-regulated gene 1) protein have been the subject of study for almost two decades. Recently, its role in the regulation of EGFR (Epidermal growth factor receptor) signaling pathway in pancreatic carcinoma has been partially elucidated. Furthermore, novel therapeutics from the group of thiosemi¬carbazone¬s were found to enhance NDRG1 expression and …more
 

Keywords

NDRG1 EGFR neuroblastoma neuroblastom cell signaling buněčná signalizace DpC thiosemicarbazones thiosemikarbazony
 
Language used: English
Date on which the thesis was submitted / produced: 1. 2. 2021
Identifier: https://is.muni.cz/th/dcrql/

Thesis defence

  • Date of defence: 18. 2. 2021
  • Supervisor: doc. RNDr. Jakub Neradil, Ph.D.
  • Reader: doc. RNDr. Alena Hyršlová Vaculová, Ph.D.

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta
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Masaryk University

Faculty of Science

Master programme / field:
Experimental Biology / Special Biology

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