Exploring Inter-subunit contact sites within the Hexameric Orai channel – Linda Victoria ECHEFU, BSc.
Linda Victoria ECHEFU, BSc.
Master's thesis
Exploring Inter-subunit contact sites within the Hexameric Orai channel
None
Exploring Inter-Subunit contact sites within the hexameric Orai1 channel
Abstract:
This study explores potential inter-subunit interactions of the hexameric Orai1 channel. Our investigation include the loss of function (LoF) mutants Orai1 K85E and E149K residues. We demonstrated that the Orai1 K85E mutation reduces homomerization via fluorescence resonance energy transfer (FRET) measurements, while the homomerization of E149k remains comparable to the Orai1 wild type In addition …moreAbstract:
This study explores potential inter-subunit interactions of the hexameric Orai1 channel. Our investigation include the loss of function (LoF) mutants Orai1 K85E and E149K residues. We demonstrated that the Orai1 K85E mutation reduces homomerization via fluorescence resonance energy transfer (FRET) measurements, while the homomerization of E149k remains comparable to the Orai1 wild type In addition …more
Language used: English
Date on which the thesis was submitted / produced: 2. 9. 2024
Thesis defence
- Supervisor: Dr. Isabella Derler
Citation record
ISO 690-compliant citation record:
ECHEFU, Linda Victoria. \textit{Exploring Inter-subunit contact sites within the Hexameric Orai channel}. Online. Master's thesis. České Budějovice: University of South Bohemia in České Budějovice, Faculty of Science. 2024. Available from: https://theses.cz/id/qy7gzp/.
The right form of listing the thesis as a source quoted
ECHEFU, Linda Victoria. Exploring Inter-subunit contact sites within the Hexameric Orai channel. České Budějovice, 2024. diplomová práce (Mgr.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
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Institution archiving the thesis and making it accessible: JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH, Přírodovědecká fakultaUNIVERSITY OF SOUTH BOHEMIA IN ČESKÉ BUDĚJOVICE
Faculty of ScienceMaster programme / field:
Biological Chemistry / Biological Chemistry
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