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Mgr. Martin Babinský, Ph.D.

Bachelor's thesis

Interakce alkaloidu berberinu s d(AAGAATTCTT)2

Interaction of berberine alkaloid with d(AAGAATTCTT)2
Abstract:
Nekovalentné interakcie planárnych aromatických systémov s nukleovými kyselinami sú v súčasnosti vďaka svojmu významu predmetom intenzívneho štúdia. Cieľom práce bolo získať a spracovať poznatky o spôsobe väzby týchto systémov na DNA s dôrazom na kvartérne protoberberínové alkaloidy. V experimentálnej časti sa pomocou NMR spektroskopie a molekulového modelovania určovala štruktúra komplexu alkaloidu …more
Abstract:
Noncovalent interactions of palanar systems and nucleic acids are being intensively studied due to their great importance. The aim of this thesis was to retrieve information about the mode of interaction between planar aromatic systems and DNA with the emphasis put on quaternary protoberberine alkaloids. The structure of complex between berberine and oligonucleotide of sequence d(AAGAATTCTT)2 has been …more
 

Keywords

kvartérne protoberberínové alkaloidy quaternary protoberberine alkaloids DNA NMR interkalácia intercalation väzba v malom žliabku groove binding
 
Language used: Czech
Date on which the thesis was submitted / produced: 25. 5. 2007
Identifier: https://is.muni.cz/th/e0mlu/

Thesis defence

  • Date of defence: 20. 6. 2007
  • Supervisor: prof. RNDr. Radek Marek, Ph.D.

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