Mgr. Michal Ďurech, Ph.D.

Bachelor's thesis

Studium interakcí lektinu RS20L se sacharidy metodami molekulového modelování

Study of interactions of RS20L lectin with saccharides using molecular modeling methods
Abstract:
This thesis is focused on bacterial lectin RS-20L from Ralstonia solanacearum, a phytopathogen that is responsible for several plant diseases. During the experimental preparation of a recombinant protein and attempts of functional characterization, several cases of very peculiar behaviour were recorded – extremely high stability of trimeric form, irreversible loss of binding properties after purification …more
Abstract:
Táto práca sa zaoberá bakteriálnym lektínom RS-20L z Ralstonia solanacearum, fytopatogénu, ktorý je zodpovedný za niektoré rastlinné choroby. V priebehu prípravy rekombinantného proteínu a pokusov o jeho funkčnú charakterizáciu bolo zaznamenaných niekoľko prípadov veľmi záhadného správania - extrémne vysoká stabilita trimérnej formy, nevratná strata väzbových vlastností po purifikácii. Výskum sa zameriava …more
 
 
Language used: Slovak
Date on which the thesis was submitted / produced: 13. 5. 2009

Thesis defence

  • Date of defence: 16. 6. 2009
  • Supervisor: prof. RNDr. Michaela Wimmerová, Ph.D.

Citation record

Full text of thesis

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta