Adéla Zaoralková

Master's thesis

WNT signalizace a její role v energetice buněčné migrace

WNT Signalling and its Role in Bioenergetics of Migrating Cells
Abstract:
Buněčná migrace je klíčový proces, který je nezbytný pro fyziologické i patologické děje. Dosud však není dostatečně objasněno, jak buňky získavají energii pro dynamické přestavby cytoskeletu. Tato práce se zaměřuje na protein Prickle3 z dráhy WNT/PCP, která tento děj reguluje. Získané výsledky ukazují, že Prickle3 má vliv na bioenergetiku buňky. Konkrétně overexprese Prickle3 zvyšuje migraci a mění …more
Abstract:
Cell migration is a fundamental process essential for both physiological and pathological events. However, it remains unsufficiently understood how cells acquire the energy required for dynamic cytoskeletal remodeling. This thesis focuses on the protein Prickle3, a component of the WNT/PCP pathway, which requlates this process. Our results demonstrate that Prickle3 significantly influences cellular …more
 

Keywords

WNT/PCP Prickle3 buněčná migrace aktin cytoskelet Enoláza1 cytochrom c cell migration actin cytoskeleton Enolase1 cytochrome c
 
Language used: Czech
Date on which the thesis was submitted / produced: 5. 5. 2026
Identifier: https://is.muni.cz/th/n4inf/

Thesis defence

  • Date of defence: 3. 6. 2026
  • Supervisor: Mgr. Jakub Harnoš, Ph.D.
  • Reader: Mgr. Michaela Dzurov Krafčíková, Ph.D.

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Lékařská fakulta
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Masaryk University

Faculty of Medicine

Master programme / field:
Specialist for Clinical Embryology and Assisted Reproduction Technology / Specialist for Clinical Embryology and Assisted Reproduction Technology

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