Bc. Nikola Siládiová

Master's thesis

Profilování membránových lipidů asociovaných s patogenezí Alzheimerovy nemoci

Profiling of membrane lipids associated with the pathogenesis of Alzheimer's disease
Abstract:
Alzheimer's disease is the most common type of dementia (60–80 %). It is widely spread especially in population over 65 years and its incidence is higher as age increasing. Diagnosis of Alzheimer's disease is very difficult and confidently determined only post-mortem. That is a reason why it is an immense effort to find new biomarkers and new reliable methods of her diagnosis preferably in the preclinical …more
Abstract:
Alzheimerova choroba je najčastejším typom demencie (60-80 %). Je veľmi rozšírená najmä v populácii nad 65 rokov a so zvyšujúcim sa vekom stúpa jej incidencia. Diagnostika Alzheimerovej choroby je ná-ročná a s istotou sa dá stanoviť až pri pitve. Preto je veľká snaha o ná-jdenie nových biomarkerov a nové spoľahlivé metódy jej stanovenia, najlepšie už v prelinických štádiach ochorenia. S patogenézou …more
 

Keywords

Alzheimerova choroba amyloidná kaskáda neurofibrilárné klbká gangliozid Ultra-účinná kvapalinová chromatografia hmotnostná spektrometria Alzheimer's disease the amyloid cascade hypothesis neurofibrillary tangles ganglioside ultra highperformance liquid chromatography mass spectrometry
 
Language used: Slovak
Date on which the thesis was submitted / produced: 18. 6. 2020
Identifier: https://is.muni.cz/th/kiw26/

Thesis defence

  • Date of defence: 9. 7. 2020
  • Supervisor: PharmDr. Zdeněk Spáčil, Ph.D.
  • Reader: Ing. Eva Cífková, PhD

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta
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Masaryk University

Faculty of Science

Master programme / field:
Biochemistry / Analytical Biochemistry

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