Bc. Lenka Kovalíková

Master's thesis

Exprese proteinu Schlafen 11 u karcinomu ovaria

Expression of Schlafen 11 in ovarian cancer
Abstract:
Tato diplomová práce je zaměřena na optimalizaci IHC protokolu pro stanovení exprese jaderného proteinu Schlafen 11 jako možného prediktivního biomarkeru rezistence ovariálního karcinomu na chemoterapii založenou na platinových derivátech. Exprese proteinu Schlafen 11 v nádorové tkáni podle dosud dostupných informací koreluje se senzitivitou k léčbě preparáty cílícími na poškození DNA. Praktická část …more
Abstract:
The objective of this thesis was to focus on the optimalization of the IHC protocol for determining the expression of the nuclear protein Schlafen 11 and its potential as a predictive marker of ovarian carcinoma's resistance to platinum derivates-based chemotherapy. According to the information available thus far, the expression of protein Schlafen 11 in the tissue of a tumor corelates with sensitivity …more
 
 
Language used: Czech
Date on which the thesis was submitted / produced: 19. 5. 2022

Thesis defence

  • Date of defence: 20. 6. 2022
  • Supervisor: MUDr. Jitka Hausnerová
  • Reader: Mgr. Lenka Zlámalíková

Citation record

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta

Masaryk University

Faculty of Science

Master programme / field:
Bioanalytical Laboratory Diagnostics in Medicine - Bioanalytic / Bioanalytical Laboratory Diagnostics in Medicine - Bioanalyst