Regulation of interactions and activity of oncoproteins MDM2 and MDMX – Mgr. Pavlína Kosztyu, Ph.D.
Mgr. Pavlína Kosztyu, Ph.D.
Doctoral thesis
Regulation of interactions and activity of oncoproteins MDM2 and MDMX
Regulation of interactions and activity of oncoproteins MDM2 and MDMX
Abstract:
Nádorový supresor p53 hraje klíčovou roli v regulaci buněčné odpovědi na nejrůznější formy buněčného stresu. Za normálních podmínek je hladina aktivního p53 v buňkách udržována na nízké úrovni především díky přítomnosti onkoproteinů Mdm2 a MdmX. Na druhou stranu, nadměrná exprese onkogenů Mdm2 a MdmX bývá příčinou inaktivace p53 u mnoha typů nádorů. Zatímco zvýšená exprese Mdm2 vede k degradaci p53 …moreAbstract:
Tumor suppressor p53 has a key role in the regulation of cellular responses to various types of stress. Its function is kept under tight control in unstressed cells primarily by interactions with oncoproteins Mdm2 and MdmX. On the other hand, overexpression of Mdm2 and MdmX is responsible for p53 inactivation in a significant proportion of tumors. While overexpression of Mdm2 leads to p53 degradation …more
Language used: English
Date on which the thesis was submitted / produced: 30. 9. 2014
Identifier:
https://is.muni.cz/th/qd0h8/
Thesis defence
- Date of defence: 28. 11. 2014
- Supervisor: Mgr. Stjepan Uldrijan, CSc.
Citation record
ISO 690-compliant citation record:
KOSZTYU, Pavlína. \textit{Regulation of interactions and activity of oncoproteins MDM2 and MDMX}. Online. Doctoral theses, Dissertations. Brno: Masaryk University, Faculty of Medicine. 2014. Available from: https://theses.cz/id/xxf9q2/.
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Institution archiving the thesis and making it accessible: Masarykova univerzita, Lékařská fakultaMasaryk University
Faculty of MedicineDoctoral programme / field:
Medical Biology (4-years) / Medical Biology
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