Bc. Ondřej Hylse
Master's thesis
Inhibitory a aktivátory proteinových kináz
Inhibitors and activators of protein kinases
Abstract:
Synteticky lethální kombinace inhibice proteinové kinázy CHK1 a aplikace cytostatik poškozujících DNA p53-deficitních rakovinných buněk se zdá být nadějnou terapeutickou strategií v moderní onkologii. Tato diplomová práce se zabývá syntézou dvou CHK1 inhibitorů na bázi pyrazolo[1,5-a]pyrimidinu s důrazem na popis přípravy nového trifluormethylovaného analogu inhibitoru SCH900776 využívající metod organofluorové …moreAbstract:
The synthetic lethal combination of inhibition of CHK1 protein kinase and application of DNA-damaging agents in p53-deficient cancer cells appears to be promising therapeutic strategy in modern oncology. This thesis describes the synthesis of two CHK1 inhibitors based on pyrazolo[1,5-a]pyrimidine scaffold. Mainly, the preparation of novel trifluoromethylated analog of SCH900776 inhibitor by means of …more
Language used: English
Date on which the thesis was submitted / produced: 9. 5. 2013
Identifier:
https://is.muni.cz/th/q77z9/
Thesis defence
- Date of defence: 13. 6. 2013
- Supervisor: doc. Mgr. Kamil Paruch, Ph.D.
Full text of thesis
Contents of on-line thesis archive
Published in Theses:- světu
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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakultaMasaryk University
Faculty of ScienceMaster programme / field:
Chemistry / Organic Chemistry
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