Preparation of novel cyclophilin D inhibitors with the use of fragment based drug design method – Monika Mrňavá
Monika Mrňavá
Master's thesis
Preparation of novel cyclophilin D inhibitors with the use of fragment based drug design method
Preparation of novel cyclophilin D inhibitors with the use of fragment based drug design method
Abstract:
Cyclophilin D (CypD) is a key regulator of mitochondrial permeability and is involved in many biological processes in which it controls the rate of protein folding and transport via catalysis of peptidyl-prolyl cis-trans isomerization. Recent research shows that CypD is a potential target in the treatment of neurodegeneration, cancer, or Chagas' disease. However, the development of new drugs is accompanied …more
Language used: English
Date on which the thesis was submitted / produced: 16. 12. 2022
Identifier:
http://evskp.uhk.cz/eM7425
Thesis defence
- Date of defence: 16. 1. 2023
- Supervisor: PharmDr. Ondřej Benek, Ph.D.
- Reader: prof. Ing. Antonín Lyčka, DrSc.
Citation record
ISO 690-compliant citation record:
MRŇAVÁ, Monika. \textit{Preparation of novel cyclophilin D inhibitors with the use of fragment based drug design method}. Online. Master's thesis. Hradec Králové: University of Hradec Králové, Faculty of Science. 2022. Available from: https://theses.cz/id/7741c7/.
Full text of thesis
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Published in Theses:- Soubory jsou od 20. 1. 2023 dostupné: světu
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Institution archiving the thesis and making it accessible: Univerzita Hradec KrálovéUniversity of Hradec Králové
Faculty of ScienceMaster programme / field:
Chemie / Toxikologie a analýza škodlivin
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