The involvement of non-histone DNA-binding HMGB1 and HMGB2 proteins in human embryonic stem cells and their differentiated derivatives – Alireza Jian Bagherpoor
Alireza Jian Bagherpoor
Doctoral thesis
The involvement of non-histone DNA-binding HMGB1 and HMGB2 proteins in human embryonic stem cells and their differentiated derivatives
The involvement of non-histone DNA-binding HMGB1 and HMGB2 proteins in human embryonic stem cells and their differentiated derivatives
Abstract:
HMGB1 a HMGB2 jsou evolučně vysoce konzervované proteiny, které se vážou s DNA a zvyšují přístup transkripčním proteinům ke specifickým oblastem na DNA. HMGB1/2 se účastní celé řady buněčných procesů včetně replikace, transkripce, opravy DNA, proliferace, diferenciace, apoptózy a růstu nádorů. Doposud nebylo známo, zda se tyto proteiny účastní regulace typických funkcí lidských embryonálních kmenových …moreAbstract:
The HMGB1 and HMGB2 are evolutionarily highly conserved non-histone nuclear proteins that bind to DNA and elevate access to transcriptional proteins on specific targets. In addition, these chromatin binding proteins have been involved in numerous cellular processes, including replication, regulation of gene transcription, DNA repair, proliferation, differentiation, apoptosis, and tumor growth. It is …more
Language used: English
Date on which the thesis was submitted / produced: 13. 3. 2017
Identifier:
https://is.muni.cz/th/fun6w/
Thesis defence
- Date of defence: 17. 5. 2017
- Supervisor: RNDr. Michal Štros, DrSc.
- Reader: doc. Mgr. Ctirad Hofr, Ph.D., doc. RNDr. Andrea Ševčovičová, Ph.D.
Citation record
ISO 690-compliant citation record:
JIAN BAGHERPOOR, Alireza. \textit{The involvement of non-histone DNA-binding HMGB1 and HMGB2 proteins in human embryonic stem cells and their differentiated derivatives}. Online. Doctoral theses, Dissertations. Brno: Masaryk University, Faculty of Science. 2017. Available from: https://theses.cz/id/gnr15t/.
Full text of thesis
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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakultaMasaryk University
Faculty of ScienceDoctoral programme / field:
Biology (4-years) / Molecular and Cellular Biology
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