Bc. Kateřina Henzlová

Master's thesis

Úloha cílových molekul miRNA v biologii solidních nádorů a hematologických malignit

The role of miRNA targets in the biology of solid and haematological malignancies.
Abstract:
MicroRNA jsou důležité regulátory genové exprese na post-transkripční úrovni, jejichž deregulace byla popsána u mnoha solidních nádorů i hematologických malignit. Diplomová práce se zaměřuje na úlohu miR-150 a miR-155 u kolorektálního karcinomu, jejich souvislost s prognózou, asociaci s klinickými charakteristikami nemoci a mechanismus působení.
Abstract:
MicroRNA's are important regulators of gene expression at post transcriptional level and their deregulation has been described in many solid tumours and hematologic malignancies. This diploma thesis is focused on the role of miR-150 and miR-155 in colorectal cancer pathogenesis, their association with prognosis and clinical features and also mechanism of action.
 

Keywords

miR-150 miR-155 kolorektální karcinom colorectal cancer GAB1 microRNA
 
Language used: Czech
Date on which the thesis was submitted / produced: 11. 5. 2017
Identifier: https://is.muni.cz/th/ct3fd/

Thesis defence

  • Date of defence: 7. 6. 2017
  • Supervisor: doc. MUDr. Mgr. Marek Mráz, Ph.D.

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta
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Masaryk University

Faculty of Science

Master programme / field:
Experimental Biology / Molecular Biology and Genetics

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