Bc. Miriam Štolcová

Master's thesis

Vývoj a základní validace LC – MS metody pro stanovení antiepileptik v biologické matrici odebírané minimálně invazivním způsobem

HPLC method development for antiepileptics determination from biological matrix obtained by minimally invasive fashion
Abstract:
This thesis deals with LC-MS determination of selected antiepileptics in dried blood spot (DBS) and saliva. Specifically, it was carbamazepine, lamotrigine, levetiracetam, lacosamide and eslicarbazepine acetate. The theoretical part describes the basic characteristics of the selected drugs, alternative types of samples and the specifics of the LC-MS connection. In the experimental part, the extraction …more
Abstract:
Diplomová práca sa zaoberá LC-MS stanovením vybraných antiepileptík v suchej krvnej škvrne (DBS) a v slinách. Konkrétne sa jednalo o karbamazepín, lamotrigín, levetiracetam, lakosamid a eslikarbazepín acetát. Teoretická časť popisuje základnú charakteristiku vybraných liečiv, alternatívne typy vzoriek a špecifiká spojenia LC-MS. V experimentálnej časti bol navrhnutý postup extrakcie daných liečiv z …more
 
 
Language used: Slovak
Date on which the thesis was submitted / produced: 18. 5. 2023

Thesis defence

  • Date of defence: 13. 6. 2023
  • Supervisor: Mgr. Marta Pelcová, Ph.D.
  • Reader: doc. PharmDr. Jan Juřica, Ph.D.

Citation record

Full text of thesis

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta

Masaryk University

Faculty of Science

Master programme / field:
Bioanalytical Laboratory Diagnostics in Medicine - Bioanalytic / Bioanalytical Laboratory Diagnostics in Medicine - Bioanalyst