RNDr. Bc. Eliška Vrbová, Ph.D.

Doctoral thesis

Treponema pallidum in clinical isolates: from diagnostics to whole genome sequencing

Treponema pallidum in clinical isolates: from diagnostics to whole genome sequencing
Abstract:
Tato práce je zaměřena na infekce způsobené patogenními spirochetami. Nejprve se zaměřuje na Treponema pallidum subsp. pallidum, původce syfilis, kde popisuje úlohu polymorfismu TLR2 při získávání infekce syfilis a jeho možný ochranný účinek. Dále pak analyzuje využití PCR v diagnostice syfilis a molekulární typizaci izolátů T. pallidum subsp. pallidum v České republice v letech 2004-2022. Za druhé …more
Abstract:
This work is focused on infections caused by pathogenic spirochetes. Firstly, it focuses on Treponema pallidum ssp. pallidum, the causative agent of syphilis. It describes the role of TLR2 polymorphism in acquiring syphilis infection and its possible protective effect. Further, it analyses the use of PCR in syphilis diagnostics and molecular typing of T. pallidum ssp. pallidum isolates in the Czech …more
 
 
Language used: English
Date on which the thesis was submitted / produced: 14. 9. 2023

Thesis defence

  • Date of defence: 16. 11. 2023
  • Supervisor: prof. MUDr. David Šmajs, Ph.D.
  • Reader: RNDr. Petra Mosio, Ph.D., María de los Ángeles Pando

Citation record

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Lékařská fakulta