Bc. Marek Vavruša

Master's thesis

Program pro analýzu rodin sekvencí schopných tvořit kvadruplexy

Computational analysis of sequence families in DNA quadruplexes.
Abstract:
V práci je představen automatizovaný přístup pro klasifikaci G-kvadruplexů do rodin podle jejich topologie, a zároveň nová metoda pro heuristickou predikci topologie G-kvadruplexu z nukleotidové sekvence. Obě metody jsou implementovány v rámci nové sady nástrojů, a porovnány se stávajícími přístupy.
Abstract:
The thesis presents an automated approach on the G-quadruplex structure classification with respect to the structure topology, and a novel method for heuristic prediction of a G-quadruplex topology from the nucleotide sequence. As a result, tools for both classification and prediction are developed and evaluated.
 

Keywords

DNA sequence analysis DNA conformation G-DNA quadruplex tetraplex machine learning classification pattern recognition
 
Language used: English
Date on which the thesis was submitted / produced: 23. 5. 2014
Identifier: https://is.muni.cz/th/wrx9l/

Thesis defence

  • Date of defence: 23. 6. 2014
  • Supervisor: Ing. Matej Lexa, Ph.D.
  • Reader: Ing. Tomáš Martínek, Ph.D.

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