Bc. Ján Tungli

Bachelor's thesis

Studium duplexu DNA interagujícího s homeodoménou Engrailed pomocí spektroskopie NMR

NMR study of a DNA duplex inertacting with the Engrailed homeodomain
Abstract:
The subject matter of this work is concerned with the study of an oligonucleotide and its interaction with a protein using NMR spectroscopy. It deals with assignment of chemical shifts of hydrogen atoms in the oligonucleotide and analysis of changes in these chemical shifts and changes of intensities in measured spectra, induced by the interaction with the protein. For the assignment of chemical shifts …more
Abstract:
Táto práca sa zoberá štúdiom oligonukleotidu a jeho interakcie s proteinom pomocou NMR spektroskopie. Rozoberá sa v nej priradenie chemických posunov vodíkových atómov oligonukleotidu a pozorovanie zmien týchto chemických posunov a zmien intenzít v nameraných spektrách vyvolaných interakciou s proteinom. K priradeniu chemických posunov boli využité data z NMR spektier NOESY a predpoklad, že sekundárna …more
 

Keywords

NMR NOESY B-DNA interakce protein-DNA interaction protein-DNA
 
Language used: Slovak
Date on which the thesis was submitted / produced: 23. 5. 2016
Identifier: https://is.muni.cz/th/s3ey8/

Thesis defence

  • Date of defence: 24. 6. 2016
  • Supervisor: prof. Dr. Jiří Kozelka, PhD.

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