Mgr. Matej Adámik

Bachelor's thesis

Interakce mutantních forem p53 s nádorovými supresory p63 a p73

Interaction of mutant p53 with p63 and p73 tumor suppressors
Abstract:
In this thesis the protein-protein interactions between purified mutant p53 and purified protein core domains p63 and p73 were analyzed. Interactions were studied by imunoprecipitation in vitro. One of the most abundant p53 mutants – R175H and the isolated core domains of p63 a p73 were investigated. Obtained results were in accord with published data, unlike studied isolated core domains, describing …more
Abstract:
Táto práca sa zameriava na štúdium interakcií purifikovaných mutantných proteínov p53 s centrálnymi doménami p63/p73. Interakcie jedného z najčastejšie sa vyskytujúcich mutantných proteínov – R175H s izolovanými centrálnymi doménami p63 a p73 boli skúmané imunoprecipitačnou technikou in vitro. Získané výsledky boli v súlade so závermi zverejnenými v literatúre, tie však pochádzali z experimentov s …more
 
 
Language used: Slovak
Date on which the thesis was submitted / produced: 12. 5. 2011

Thesis defence

  • Date of defence: 14. 6. 2011
  • Supervisor: Mgr. Marie Brázdová, Ph.D.

Citation record

Full text of thesis

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta

Masaryk University

Faculty of Science

Bachelor programme / field:
Biochemistry / Biochemistry